Abstract
A solid phase synthesis method was established for the synthesis of peptide-poly(ethylene glycol)-lipid (peptide-PEG-lipid) conjugates. Octreotide-PEG(2000)-DSPE (OPD(2000)) was used as an example to demonstrate the synthetic approach. The OPD(2000) obtained had confirmed structure, activity, and purity providing a targeting molecule for preparation of well-defined drug delivery systems, such as targeted liposomes, for further studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Chemistry, Pharmaceutical / methods
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Chromatography / methods
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Drug Delivery Systems
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Kinetics
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Ligands
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Lipids / chemistry*
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Liposomes / chemistry
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Molecular Conformation
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Octreotide / chemistry*
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Peptides / chemistry*
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Phosphatidylethanolamines / chemistry*
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Polyethylene Glycols / chemistry*
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Substances
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Ligands
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Lipids
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Liposomes
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Peptides
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Phosphatidylethanolamines
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polyethylene glycol-distearoylphosphatidylethanolamine
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Polyethylene Glycols
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Octreotide